Inflammatory myofibroblastic tumor histology

Inflammatory myofibroblastic tumor histology. We retrospectively searched for records All the spindle cells reacted strongly to antibodies against vimentin and calponin, whereas a subset of the spindle cells expressed smooth muscle actin and desmin. 1, 2, 3 Laryngeal IMT has been reported most commonly in the vocal folds, although a few cases in the aryepiglottic folds have been reported. The differential diagnosis is broad, and diagnosis typically requires surgical excision. We report the case of a three-year-old child who suffered from a chronic cough with recurrent respiratory infections. in 1954 because of its clinical and radiological behavior that mimics a malignant process [ 1 ]. The tumor may recur and rarely metastasizes. All the lesions were incidentally discovered at delivery or … Sep 22, 2009 · It is also known as pseudosarcoma, atypical myfibroblastic tumor, atypical fibromyxoid tumor, plasma cell granuloma, etc. These tumors have been divided into the following categories on the basis of their biologic behavior: benign (eg, myositis ossificans, myofibroma, fibromatosis colli), intermediate–locally aggressive (eg, lipofibromatosis Apr 4, 2020 · Postoperative microscopic pathology of the inflammatory myofibroblastic tumors. 14 IMT can occur at any site and presenting symptoms vary based on primary site of the IMT. Over the last two decades, inflammatory myofibroblastic tumour (IMT) has emerged from within the broad category of inflammatory Inflammatory myofibroblastic tumor (IMT) is a distinctive fibroblastic and myofibroblastic spindle c Clinicopathologic and Genomic Characterization of Inflammatory Myofibroblastic Tumors of the Head and Neck: Highlighting a Novel Fusion and Potential Diagnostic Pitfall : The American Journal of Surgical Pathology Inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal tumor of intermediate malignant potential that predominantly affects children, adolescents and young adults. Diagnostic challenges arise from the diverse pathological presentation, variable symptomatology, and lack of different imaging features. It is an ultra-rare tumor, the optimal management of which remains to be defined. Inflammatory myofibroblastic tumor (IMT) is a Dec 18, 2014 · Objectives To present the most important characteristics of inflammatory myofibroblastic tumours (IMTs) arising in different locations of the body with histological correlation. Over time, however, IMT cases occurred in which the tumor spread into local tissues, metastasized to distal tissues, recurred after treatment, or consisted of neoplastic cells Inflammatory myofibroblastic tumors (IMTs) of the uterus are often associated with pregnancy and are delivered with the placenta. [1-3] "An inflammatory myofibroblastic tumor exhibiting immunoreactivity to KIT: a case report focusing on a diagnostic pitfall. Jun 30, 2017 · Inflammatory myofibroblastic tumors of the uterus are rare, and although most have a favorable prognosis, a small subset exhibit extrauterine disease, recur, or cause death. The tumor is composed of spindle-shaped myofibroblasts with fascicles or storiform patterns and sometimes within loose myxoid stroma. Apr 12, 2021 · The diagnosis of benign and malignant soft tissue and bone neoplasms is a challenging area of surgical pathology, due to the large number, rarity, and histologic diversity of tumor types. (A) Long spindle cells contained small nuclei with vesicular chromatin and scattered plasma cells and lymphocytes. The tumour is composed of an admixture of spindle-shaped and ovoid cells with a prominent inflammatory infiltrate (figures 2–3). It is also known as plasma cell granuloma, inflammatory myofibrohistiocytic proliferation, omental Aug 16, 2021 · Inflammatory myofibroblastic tumors (IMTs) are a rare solid mesenchymal tumor commonly documented in children and young adults. Owing to its rarity, however, IMT remains poorly understood. 2022 May;69(5):e29460. May 18, 2024 · A boy aged 55 months was diagnosed with stage IV Neuroblastoma (NB) of the right adrenal gland 2 years ago. A number of terms have been applied to the lesion, namely, inflammatory Inflammatory myofibroblastic tumor (IMT) is a neoplasm of intermediate biologic potential. However, its management has never Jul 7, 2023 · Inflammatory myofibroblastic tumor (IMT) of the biliary tract is rare, and often difficult to diagnose or to distinguish from other tumors due to its atypical clinical presentation and nonspecific radiological features. After surgery, the children were transferred to the Hemato-Oncology Department for chemotherapy according to the high-risk group NB, with outpatient follow-up every May 1, 2019 · Inflammatory myofibroblastic tumor of the spleen (IMTS) is an extremely rare, intermediate malignant tumor with unclear etiology, and is most frequently detected incidentally. We studied 11 uterine IMTs with typical histology and 8 uterine myxoid smooth muscle tumors (5 leiomyomas, 1 smooth muscle tumor of uncertain malignant potential, and 2 leiomyosarcomas) in which the differential of IMT was considered, using a RNA-sequencing–based fusion assay to detect genetic fusions involving ALK, ROS1, RET, NTRK1/3, and other genes. doi : 10. ; Thought to arise from the pericyte, a connective tissue cell of small vessels that is thought to be involved in flow regulation while others consider a fibroblastic nature. Modern Pathology Jul 27, 2016 · Inflammatory myofibroblastic tumor (IMT) is a distinct mesenchymal neoplasm composed of spindled fibroblastic and myofibroblastic cells in a myxoid to collagenous stroma containing abundant lymphocytic and plasmacytic inflammatory infiltrate . IMT has a predilection for the lung, abdomen, pelvis, and retroperitoneum, however, can affect any part of the body. IMT is rare in the … Mar 3, 2022 · A database searches in the pathology archives by using the term “inflammatory myofibroblastic tumor” and” bladder” in our hospital department of pathology from 2010 to 2021. Jul 11, 2013 · The lack of necrosis and absence of staining for CD23 used as a substitute for CD21, further confirmed the exclusion of nodular fasciitis and follicular dendritic tumor, respectively. It has a low but definite malignant potential. These tumors have nonspecific clinical features and various radiological appearances. Apr 19, 2016 · Inflammatory myofibroblastic tumor is a neoplasm of intermediate biological aggressiveness and is classified among the fibroblastic—myofibroblastic tumors. Half of inflammatory myofibroblastic tumors (cases 1–6) showed a predominantly diffuse myxoid or edematous stroma with variably collagenized areas Jan 16, 2020 · Inflammatory Myofibroblastic Tumor. Best classified as a neoplasm of uncertain malignant potential, as histologically bland uterine confined tumors may recur. Jul 27, 2016 · Inflammatory myofibroblastic tumor (IMT) is a distinct mesenchymal neoplasm composed of spindled fibroblastic and myofibroblastic cells in a myxoid to collagenous stroma containing abundant lymphocytic and plasmacytic inflammatory infiltrate . Genetically, most IMTs harbor tyrosine Apr 5, 2015 · Inflammatory myofibroblastic tumors are uncommon neoplasms; presentation of these tumors in the lower extremities is extremely rare. We reviewed data from eight patients diagnosed with pulmonary IMT (PIMT) at our hospital with the aim of summarizing and analyzing the characteristics of PIMT to improve our understanding of Jul 27, 2022 · An inflammatory myofibroblastic tumor (IMT) is a neoplasm composed of myofibroblastic and fibroblastic spindle cells accompanied by inflammatory cells, including lymphocytes and eosinophils. Dec 12, 2012 · INTRODUCTION. 6 Two reports exist of peritoneal masses in horses in which tumor cells were confirmed to be of myofibroblastic origin, but neither mass had a significant inflammatory Aug 1, 2021 · Section snippets Clinical presentation. Surgery is the treatment of … Jul 1, 2023 · Approximately half of inflammatory myofibroblastic tumors harbor anaplastic lymphoma kinase (ALK) fusion genes, and the other half could have potentially targetable fusion genes or mutations such as ROS1, NTRK and RET; case reports demonstrating the clinical efficacy of treatments targeted to inflammatory myofibroblastic tumor have been Dec 1, 2021 · Inflammatory myofibroblastic tumor (IMT) is a distinctive fibroblastic and myofibroblastic spindle cell neoplasm with an accompanying inflammatory cell infiltrate and frequent receptor tyrosine kinase activation at the molecular level. The median age at diagnosis is 9 years of age 2, 14 with a female to male ratio of 1. Methods: To review the symptoms and main radiological findings of IMTs. The clinical and pathological features of IMT in adult patients are not well understood. IMT is rare and its true incidence and prevalence remains unclear ( 1 ). Much of the confusion has been caused by the varying degrees of inflammatory cell infiltration noted on pathologic examination and the observation that the disease process, although usually Aug 12, 2022 · Inflammatory myofibroblastic tumor (IMT) is a rare myofibroblastic neoplasm that most frequently occurs in children and young adults. Magnification, ×400. In this study, we report a subset of IMTs with histologic atypia and/or clinical aggressiveness that were analyzed for clinicopathologic features, outcome, and immunohistochemical expression of anaplastic lymp … Inflammatory myofibroblastic tumor, or IMT, forms in tissues called mucosal surfaces and mesentery. Immunohistochemistry results were consistent with a myofibroblastic derivation for the spindle-cell population and the diagnosis of inflammatory myofibroblastic tumor (IMT) was made. Jul 4, 2024 · Introduction: Inflammatory pseudotumor encompasses a broad range of non-neoplastic and neoplastic entities, including inflammatory myofibroblastic tumors (IMTs). ). Oct 1, 2014 · Inflammatory myofibroblastic tumor and other spindle cell lesions of the urinary bladder represent one of the most difficult diagnostic dilemmas in genitourinary pathology because of significant overlap between benign and malignant processes in terms of clinical presentation, gross findings, morphology, and immunoprofile. Sarcomas as a whole are characterised by an incidence of approximately 5 cases/100,000 thus matching the formal definition of a rare tumor 6. Inflammatory myofibroblastic tumor (IMT) is a curious low grade tumor consisting of a proliferation of myofibroblastic cells with a variable admixture of inflammatory cells . Jul 17, 2012 · Inflammatory myofibroblastic tumor is a rare benign lesion whose tumor origin is now proven. Often affecting … Oct 28, 2010 · Inflammatory myofibroblastic tumor (IMT) is a distinctive mesenchymal neoplasm characterized by a spindle-cell proliferation with an inflammatory infiltrate. Nov 8, 2023 · Inflammatory myofibroblastic tumor (IMT), characterized by intermediate malignancy and a propensity for recurrence, has presented a formidable clinical challenge in diagnosis and treatment. They have also been described in the literature under names such as atypical myofibroblastic tumor, pseudosarcomatous Jan 1, 2020 · Inflammatory myofibroblastic tumors of the urinary tract: A clinicopathologic study of 46 cases, including a malignant example inflammatory fibrosarcoma and a subset associated with high-grade urothelial carcinoma. Its pathological characteristics may resemble other neoplasms or reactive lesions, and the treatment was limited, taking chemotherapies as the only option for those inoperable. Histologically, IMTs are (myo)fibroblastic a small subset of myxoid leiomyosarcomas is ALK-positive. Jun 20, 2024 · Inflammatory myofibroblastic tumor (IMT) is a rare neoplasm with intermediate malignancy characterized by a propensity for recurrence but a low metastatic rate. ALK was expressed in 10 of Pathology Clinic Inflammatory Myofibroblastic Tumor Lester D. Imaging findings reflect pathologic features and vary from an ill-defined, infiltrating lesion to a wellcircumscribed, soft tissue mass owing to variable inflammatory, stromal, and myofibroblastic Mar 1, 2022 · Inflammatory myofibroblastic tumors (IMTs) are rare intermediate-grade neoplasms that have a high recurrence rate after excision and exhibit low metastatic potential. Objectives: To present the most important characteristics of inflammatory myofibroblastic tumours (IMTs) arising in different locations of the body with histological correlation. 8 IMT of the larynx, trachea, kidney, urinary bladder The inflammatory myofibroblastic tumor (IMT) is a distinctive but controversial lesion, usually occurring during childhood, composed of fascicles of bland myofibroblastic cells admixed with a prominent inflammatory infiltrate consisting of lymphocytes, plasma cells, and eosinophils. 1 It is a soft tissue tumor, which evolves through myofibroblastic differentiation and is characterized by the infiltration of inflammatory cells into the tissue. Feb 1, 2023 · Inflammatory myofibroblastic tumor (IMT) of the uterus is a rare mesenchymal tumor with largely benign behavior; however, a small subset demonstrate aggressive behavior. Sympt … Inflammatory myofibroblastic tumor was initially regarded as a benign tumor that most often developed in the lung and less commonly in almost any organ system or tissue. Inflammatory myofibroblastic tumors (IMTs) are rare benign spindle cell tumors and characterized histologically by the myofibroblastic spindle cell proliferation accompanied by inflammatory cell infiltration. R. Introduction. Aug 9, 2018 · Most benign spindle cell tumors of the urinary bladder are an inflammatory myofibroblastic tumor (IMT). Dec 18, 2014 · To present the most important characteristics of inflammatory myofibroblastic tumours (IMTs) arising in different locations of the body with histological correlation. IMT usually starts in the lung, but it can also begin in many other places. Apr 13, 2011 · Inflammatory Myofibroblastic tumor (IMT) is a rare neoplasm consisting of variable numbers of inflammatory cells and myofibroblastic spindle cells. Inflammatory myofibroblastic tumor is recognized as a neoplastic subset that can be associated with ALK gene rearrangement and is typically seen in the younger age group. IMT is a benign and uncommon mesenchymal tumor. Which of the following is the most likely diagnosis? High grade osteosarcoma Hodgkin lymphoma Inflammatory myofibroblastic tumor Myxoinflammatory fibroblastic sarcoma Mar 3, 2023 · Inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal malignancy that occurs primarily in children and adolescents. It is often observed in the lungs, the extra pulmonary location is rare and mainly affects the intestinal mesentery and the omentum. Methods: A PubMed/Medline search was conducted, according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, using the following Mesh terms: ("inflammatory myofibroblastic") AND ("tumor") OR ("tumor") AND ("bladder") AND ("case report"). Patients’ ages Jul 7, 2021 · Inflammatory myofibroblastic tumor (IMT) is a kind of mesenchymal tumor characterized with proliferation of myofibroblast spindle cells and prominent infiltration of plasmocytes and/or lymphocytes. Epithelioid inflammatory myofibroblastic sarcoma (EIMS) is an aggressive subtype of IMT, typically involving the abdomen. DISCUSSION. Gonzalez, M. Grouped with solitary fibrous tumour in the WHO classification; share same genetic NAB2-STAT6 fusion. On ultrasonography (US), these tumours can appear as hypoechoic or hyperechoic masses and a variable Doppler appearance with increased vascularity May 23, 2022 · Inflammatory myofibroblastic tumor (IMT) is a heterogeneous malignancy with variable patterns of histology and behavior that primarily affects children and young adults. Nov 18, 2020 · Cytomorphological analysis of an inflammatory myofibroblastic tumor. Magnification Aug 1, 2021 · Inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal tumor of intermediate malignant potential that predominantly affects children, adolescents and young adults. 7% of all lung tumors. Head and neck region, is an unusual site of involvement. Jan 3, 2018 · This review covers prostatic stromal proliferations (prostatic stromal tumor of uncertain malignant potential and stromal sarcoma), solitary fibrous tumor, myofibroblastic proliferations, smooth Mar 1, 2009 · A splenic mass with marked histologic similarity to the 2 masses described in this article was reported in a dog; this mass was termed inflammatory pseudotumor by the authors. May 28, 2024 · Keywords: hepatic inflammatory myofibroblastic tumor, hepatectomy, histology, imaging, case report Introduction Inflammatory myofibroblastic tumor (IMT) of the liver, previously known as inflammatory pseudotumor (IPT), has been identified in various somatic and visceral locations, although it was originally described in the lungs. It has spindle cells in fascicular, fasciitis-like and sclerosing patterns, with heavy chronic inflammation including abundant plasma cells. IMTs are mostly found in children and young adults but can occur at any age. Surgery is the treatment of choice for localized tumors. Herein, we evaluated a series of 23 IMTs for the novel endometrial stromal markers interferon-inducible transmembrane protein-1 (IFITM1) and BCOR, the novel myoid marker transgelin, and possible predictive markers p16 and p53 by immunohistochemistry to determine their expression profile and potential prognostic value. (B) Pulmonary inflammatory myofibroblastic tumor exhibiting distinct collagenous stroma with scattered plasma cell infiltrate. IMTs are one of the most frequent lung tumors in children, accounting for between 16% and 38% of cases in various series. This rare mesenchymal tumor consists of spindle shaped fibroblasts associated with various amounts of inflammatory cells. It represents 0. IMTS presents with nonspecific symptoms that pose a diagnostic challenge to clinicians or presents with the similar appearances to splenetic malignant neoplasms that pose Dec 1, 2017 · Inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal neoplasm composed of spindled to epithelioid cells with prominent myxoid stroma and inflammatory infiltrate. IMT usually affects children and adolescents, although a broad age range has been documented. 1002/pbc. It is an unusual solid tumor commonly seen in children and young adults, and can occur at any site in the body, the lung being the most common site[]. Inflammatory myofibroblastic tumors (IMTs) occur throughout the body, but the lungs are the most commonly involved organs. Previously termed “inflammatory pseudotumor” (among many other names), inflammatory myofibroblastic tumor (IMT) is a myofibroblastic neoplasm of intermediate biologic potential that arises predominantly in children, adolescents, and young adults in the lungs, abdomen, and pelvis [74, 75]. Preoperative chemotherapy was given and he was then treated with retroperitoneal tumor resection and lymph node dissection. Inflammatory myofibroblastic tumor of the breast is an extremely rare lesion. Learn more about treatment and the prognosis for IMT. Nov 5, 2019 · Two main histologic patterns were identified. 1, 2 IMT occurs most commonly in the lungs, gastrointestinal tract, and liver, but rarely arises in the larynx. In this study, we report a subset of IMTs with histologic atypia and/or clinical aggressiveness that were analyzed for clinicopathologic features, outcome, and immunohistochemical expression of anaplastic lymphoma kinase (ALK) and other markers to identify potential pathologic prognostic features. It can affect any age group, but is more common in children and young adults The terms "inflammatory myofibroblastic tumors" and "inflammatory pseudotumors" are interchangeably used by many scientists. However, soft tissue malignancies are further subclassified in approximately 70 subtypes, each characterized by a distinct morphology, that often translates into a specific clinical behaviour as well as into specific therapeutic approaches. Essential features. The inflammatory markers were Jul 1, 2021 · The WHO soft tissue tumor pathology and genetic classification defines it as a mesenchymal tumor composed of differentiated myofibroblastic spindle cells with numerous inflammatory cells, with low-grade malignant or borderline tumor characteristics . Inflammatory myofibroblastic tumor (IMT) is a distinctive neoplasm composed of myofibroblastic and fibroblastic spindled cells accompanied by an inflammatory infiltrate of plasma cells, lymphocytes, and/or eosinophils, which has intermediate biological behavior [1,2]. 3 In decreasing order of frequency, intra-abdominal IMTs have been reported to occur in the omentum, mesentery, liver, stomach, bowel wall, and spleen. Jul 9, 2021 · Inflammatory myofibroblastic tumor of soft tissue is a histologically distinctive myofibroblastic spindle cell neoplasm of borderline malignancy, classically featuring an intermixture of plasma cells and lymphocytes. These tumors contain proliferating neoplastic, fibroblastic and myofibroblastic cells, and are also characterized by chronic inflammatory infiltration by lymphocytes, plasma cells Mar 3, 2021 · Epithelioid inflammatory myofibroblastic sarcoma: similar, except cells are more epithelioid, with large nucleoli Microscopic (histologic) images Contributed by Raul S. There is significant controversy and confusion regarding the pathogenesis and histogenesis of these uncommon tumors or tumor-like masses . 4–3. While clinicopathologic features have been previously associated with aggressive behavior, these reports are based on small series … May 28, 2008 · Inflammatory Myofibroblastic Tumor. Journal of Pathology and Aug 1, 2022 · Previously described as inflammatory pseudotumor, inflammatory myofibroblastic tumors (IMT) are now considered as distinct tumors of specific histopathologic features. Dec 28, 2023 · Inflammatory myofibroblastic tumour (IMT) is a rare mesenchymal neoplasm of intermediate malignant potential, occurring at any age and at multiple sites. Head and neck IMTs are rarely seen and comprise less than 5 % of tumors. The American Journal of Surgical Pathology, 30, 1502–1512. These tumors have been divided into the following categories on the basis of their biologic behavior: benign (eg, myositis ossificans, myofibroma, fibromatosis colli), intermediate–locally aggressive (eg, lipofibromatosis Oct 7, 2021 · Microscopic examination shows a dense inflammatory infiltrate with scattered atypical tumor cells with prominent nucleoli that resemble Reed-Sternberg cells. In this article, we will introduce two separate Inflammatory myofibroblastic tumor (IMT), a mesenchymal neoplasm of intermediate biological potential characterized by a prominent inflammatory infiltrate, is increasingly defined by recurring genomic alterations. Patient characteristics, clinical features, histopathological results, immunohistochemical staining results, and treatment outcomes were reviewed. They can occur in a wide age range and at all anatomic sites, but most frequently they can be observed in the lung (especially in pediatric cases), abdomen, or retroperitoneum. terine IMT. To review the symptoms and main radiological findings of IMTs. D. 1 Although IMTs most commonly occur in the lung, they can also present in diverse extrapulmonary locations including head and neck, abdomen, pelvic cavity, retroperitoneum Feb 1, 2024 · Methods. It was first observed in the lung and described by Brunn in 1939 and was so named by Umiker et al. It was previously thought to be reactive in nature, but recent studies have conclusively proven most cases to be neoplastic. Aug 17, 2022 · Inflammatory myofibroblastic tumor (IMT) is a rare disease. We describe the clinical, pathologic, and molecular findings in nine cases of placenta-associated IMT (PaIMT). Feb 12, 2015 · The World Health Organization (WHO) classifies inflammatory myofibroblastic tumors (IMTs) as distinct borderline lesions, while the physical history of these lesions can variably range from reactive to truly neoplastic . However, discovering Jul 10, 2024 · Inflammatory myofibroblastic tumors (IMTs) are rare soft-tissue neoplasms with unclear etiology and variable biological behaviors ranging from benign lesions to more aggressive variants. Methods To review the symptoms and main radiological findings of IMTs. Inflammatory myofibroblastic tumor (synonymous with inflammatory fibrosarcoma) is a neoplasm arising predominantly in childhood, and frequently in intraabdominal locations. 1186/1477-7819-12-186 . Inflammatory myofibroblastic tumor is also known as IMT, inflammatory pseudotumor, plasma cell granuloma and pseudo-inflammatory tumor, and it is a generic term that is applied to a variety of neoplastic and non-neoplastic entities that share a common histologic appearance, namely, a cytologically bland spindle cell proliferation with a prominent, usually chronic inflammatory Dec 21, 2017 · Inflammatory myofibroblastic tumors (IMT) are distinctive lesions of unknown etiology, composed of myofibroblastic spindle cells with an associated inflammatory background. 15 Up to one-third of the IMT cases arise in the lungs 16 and 65% of cases involve the abdomen, retroperitoneum or pelvis. The differential diagnosis includes inflammatory myofibroblastic tumor (IMT), atypical cellular myofibroma, leiomyosarcoma and nodular fasciitis among others. 1 IMT was formerly included in a wide spectrum of reactive and neoplastic lesions known as “inflammatory pseudotumors”. IMT is typi … Clinical, pathologic, and molecular features of inflammatory myofibroblastic tumors in children and adolescents Pediatr Blood Cancer . The treatment of advanced disease is not precisely defined Jul 8, 2021 · Inflammatory myofibroblastic tumor (IMT) is a kind of mesenchymal tumor characterized with proliferation of myofibroblast spindle cells and prominent infiltration of plasmocytes and/or lymphocytes. Inflammatory myofibroblastic tumor (IMT) is a rare soft-tissue tumor with a clinical resemblance to malignant neoplasm[]. On ultrasonography (US), these tumours can appear as hypoechoic or hyperechoic masses and a May 26, 2024 · Inflammatory myofibroblastic tumor is an extremely rare neoplastic lesion with a predilection for aggressive local and recurrent behavior. In recent years, diagnosis and classification has been aided substantially Sep 15, 2021 · 3. Chest X-ray and computed tomography revealed the presence of a left lower lobe lung mass. Thompson, MD1 Inflammatory myofibroblastic tumor (IMT) is a distinc-tive, rarely metastasizing, (myo)fibroblastic neoplasm composed of spindle cells accompanied by an inflamma-tory infiltrate of plasma cells, lymphocytes, and/or eosi-nophils. 3, 4 IMT primarily affects children Hemangiopericytoma General. Four cases of IMT in the lung are presented, including a young adolescent girl with an ETV6-neurotrophic tyrosine receptor kinase 3 (NTRK3) gene rearrangement, a 5-year-old boy with challenging preoperative diagnosis, and 2 middle-aged women with respectively pleural and endobronchial tumors with one peribronchial relapse. IMT is rarely encountered in the liver. After pneumonectomy, histological examination combined Histology of inflammatory myofibroblastic tumour Histologically , the lesion is based in the dermis and seen underlying a normal epidermis (figure 1). Jul 27, 2022 · An inflammatory myofibroblastic tumor (IMT) is a neoplasm composed of myofibroblastic and fibroblastic spindle cells accompanied by inflammatory cells, including lymphocytes and eosinophils. Article Google Scholar A complete organized library of all my videos, digital slides, pics, & sample pathology reports is available here: https://kikoxp. Here we report a case of a 30 year old male who presented with a rapidly Sep 27, 2021 · 1. 4 Lesions are usually 0. Methods. Uncommon mesenchymal neoplasm of myofibroblastic / fibroblastic origin with variable amounts of myxoid stroma and lymphoplasmacytic inflammation; often characterized by ALK fusions. May 1, 2019 · Introduction. Because it is a rare mesenchymal tumor of unknown etiology and pathogenesis, and its clinical symptoms and radiologic features are not distinctive, intracranial IMT could be misdiagnosed as other extra-axial tum. The most common site for this tumor is lung. It encompasses a spectrum of myofibroblastic proliferation along with varying amount of inflammatory infiltrate. However, a detailed analysis of the development of terminology suggests that the term "inflammatory myofibroblastic tumors" should be used to refer to a neoplastic lesion. A: Well demarcated firm vascularized tumor mass with spotty inflammatory infiltrate; B: Bland proliferation of spindle cells in broad fascicles at higher magnification. Inflammatory pseudotumour is a generic term applied to a variety of neoplastic and non-neoplastic entities that share a common histological appearance, namely a cytologically bland spindle cell proliferation with a prominent, usually chronic inflammatory infiltrate. Inflammatory myofibroblastic tumor (IMT) is a rare benign lesion that has similarities to malignant lesions due to possible aggressive behavior, although its specific potential for malignancy has not been determined. 3 G-IMT Feb 28, 2010 · INTRODUCTION. com/posts/5084 (dermpath) & Nov 11, 2022 · Introduction. IMT demonstrates a prominent inflammatory cell infiltrate, which is typically absent in LGMS and harbors fusions of ALK or other kinases 73. We present a case of a 47-year-old male with fever, fatigue, and a slow-growing thigh mass. Inflammatory myofibroblastic tumor (IMT) or plasma cell granuloma is a distinctive lesion composed of myofibroblastic spindle cells accompanied by an inflammatory Jul 11, 2013 · The term inflammatory myofibroblastic tumor (IMT) encompasses a diverse group of spindle cell entities that traverses a clinical and histologic spectrum, extending from reactive to benign neoplastic to highly aggressive with malignant inclinations. A total of 75 case reports were included in the analysis. 29460. Introduction: We report the clinical findings and results of treatment in the cohort of patients with inflammatory myofibroblastic tumor (IMT) managed according to the European pediatric Soft Tissue Sarcoma Study Group (EpSSG) protocol from 2005 to 2016. doi: 10. Inflammatory myofibroblastic tumor is an uncommon lesion of unknown cause. IMTs show characteristic fasciitis-like, compact spindle cell and hypocellular fibrous histologic patterns and distinctive molecular features. World J Surg Oncol 12 : 186. 4. The tumor tends to occur in the lungs of children and young adults, and although it can develop in older patients and other organs, this is extremely rare. Jul 20, 2023 · PATHOLOGY. 5 cm in size. (1–4) Among these, fusions involving ALK and ROS1 have emerged as common genetic abnormalities, although recent efforts have Sep 5, 2012 · Inflammatory myofibroblastic tumor (IMT) is a neoplasm of intermediate biologic potential. Search for more papers by this author. Mar 15, 2014 · Inflammatory myofibroblastic tumor (IMT) is an uncommon myofibroblastic neoplasm that was formerly included within the broad category of inflammatory pseudotumor (IPT). Jul 11, 2016 · Pediatric fibroblastic and myofibroblastic tumors are a relatively common group of soft-tissue proliferations that are associated with a wide spectrum of clinical behavior. Dec 14, 2018 · Pathology and immunohistochemistry analysis is the key to the diagnosis of primary gastric myofibroblastic tumors, especially ALK, which can be used as an identifying factors for IMT and gastrointestinal stromal tumors (GISTS), smooth muscle neoplasm, inflammatory fibrous polyps, solitary fibrous tumor, peripheral nerve sheath tumors Mar 6, 2013 · Department of Pathology, Central University Hospital, 33306 Oviedo, Spain. Inflammatory myofibroblastic tumor (IMT) is a neoplasm of intermediate biologic potential. It is idiopathic and no known predisposing condition exist for myofibroblastic tumor of the bladder. ". Similar to IMT of other organs, the interchangeable use of the terms IMT and IPT in liver has made the analysis of these lesions difficult. [1, 2, 3] Although the urinary bladder and rarely, the ureter, are affected, this lesion has been described in numerous other locations. The present study reported on five cases of gastric IMT and indicated that the tumor formed a Nov 3, 2020 · Rarity. ucmu hzyd jyz jxt fcbxgxf rdsg yraalp yxjhk hdnxt umdeoc